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SKIN REGENERATION Skin Rejuvenation

What Are Skin Stem Cells?

Within every human body lies a natural reservoir of specialized cells tasked with a vital mission: maintaining the integrity of tissues—such as the skin and blood—where individual cells possess short lifespans and undergo continuous turnover. To sustain this constant rejuvenation and replace cellular loss, our bodies rely on cells equipped with the extraordinary capacity to regenerate and replenish. These cellular architects are known as "stem cells." To be scientifically categorized as a true stem cell, the following twin definitive capabilities are absolutely essential:

One is the ability to produce the various cells that make up our bodies, such as skin, red blood cells, and platelets (differentiation ability), and the other is the ability to divide into cells with exactly the same abilities as itself (self-replication ability).

Stem cells are broadly divided into two types. One type is stem cells that continue to produce replacements for lost cells in specific tissues and organs, such as skin and blood. This type of stem cell is called a "somatic stem cell". Somatic stem cell cannot become anything; they have a specific role, such as hematopoietic stem cells that create blood and neural stem cells that create the nervous system. The other type is a "pluripotent stem cell," which can produce any cell in our body, like ES cells (embryonic stem cells).

In other words, pluripotent stem cells can also produce various somatic stem cells that exist in our bodies. iPS cells (induced pluripotent stem cells) are "pluripotent stem cells" artificially created from ordinary cells. Using these properties of "stem cells," research is underway on a new type of treatment called "regenerative medicine," which uses the cells themselves as medicine to heal injuries and diseases, and on reproducing the state of cells inside the body outside the body to investigate the mechanisms of disease.

Preventative Care for Aging Skin

Autologous Adipose-Derived MSC Therapy: Preventing the Progression of Aging Skin

Anti-aging Skin Care

Stem cells are incredible cells that have the unique ability to replace old cells and replenish the ones we’ve lost. As our skin ages, we naturally lose that baby-smooth skin, but those youthful "baby cells" actually stay with us even as we grow older. Those are the stem cells. They work to regenerate fresh, new skin and beautifully revive your own natural glow.

Perfect for Cellular Skin Injections

To keep your face looking youthful, the dermis—which serves as the very foundation of your skin—is the most important part. The main components of this dermis are "fibroblasts" and the "mesenchymal stem cells" they originate from. By injecting these cells, your skin begins to naturally produce its own essential dermal components, including collagen, elastin, and hyaluronic acid.

If the dermis is aging and has sustained tissue damage, the injected stem cells will naturally use "homing effect" on the damaged area (gathering there) to produce fresh collagen and actively repair the damage.

The Treatment Flow

Helene clinic could provide medical service to patients not only in Japanese, but also in Chinese, Vietnamese, English, French, and Mongolian...etc.

1Appointments

After receiving your inquiry, our staff will confirm the date of your visit and make a reservation. We will notify you when your reservation is complete.

To schedule your appointment, please ensure you have the following credentials ready for submission: Clinical Documentation: Official medical records or a comprehensive health examination report verifying your current health status (issued within the last 3 months). Identity Verification: A valid government-issued photo identification (passport).

For foreign patients
Please apply through a medical coordinator.

2Counseling

You will be requested to complete a comprehensive medical questionnaire to map your detailed health history. Base on your health records and current clinical profile, our medical team will design a highly customized therapeutic tailored to your unique physiological needs.

3Cell Collection & Blood Sampling

The entire procedure approximately 20 minutes, and will use local anesthesia.
A small adipose tissue sample (approximately 5 mm in diameter) will be harvested from the discreet area behind the ear, after that the blood sampling will be taken.
The suture material is highly biocompatible, medical-grade bioabsorbable sutures.
After the cell sample being collected, Helene medical team will check the wound and provide you medicine.

※ The suture is bioabsorbable, no removal required.

4Payment

Helene clinic is an elective care clinic.
Counseling is free of charge, the payment will be required once the cell sample being collected.
Payment could be made by credit card (JCB not accepted), UnionPay, WeChat Pay, Alipay, Line Pay, and international transfer .

5Cell Culture

We will begin culturing stem cells in our own laboratory.
The culture period is approximately 4 weeks.
We begin cell culture in optimal condition according to your administration date, so please refrain from changing or canceling your administration date.

Helene Clinic In-house Lab (CPC)

Many regenerative medicine clinics currently obtain cultured cells by outsourcing cell culture operations or purchasing them from external sources. However, at our clinic, we have established an in-house CPC (Cell Processing Center), and all processes from collection to storage, culture, and testing are performed in the same laboratory, with everything centrally managed using barcodes. We meet management standards equivalent to GMP and have also obtained ISO 9001 certification.

Proprietary Medium Formulation

The most important factor in high-quality cell culture is the medium. At Helene clinic, we use "Helene Medium," a proprietary in-house developed culture medium specifically engineered for mesenchymal stem cells within our state-of-the-art laboratory. The growth curve and growth rate of this medium are stable, even without the serum presence. Also, it is thousand times faster in cultivation than other available medium. These experimental results have been presented at overseas conferences such as [1] ISCT (the International Society for Cellular Therapy) and [2] Cambridge International Stem Cell Symposium.

[1] “Cartilage regeneration by autologous adipose-derived mesenchymal stem cells for the treatment of osteoarthritis” was posted in ISCT (the International Society for Cellular Therapy) from May 29 to June 1, 2019
(http://www.isct2019.com/)

[2] “The Helene Medium: Specialized Stem Cell Culture Medium” was in Cambridge International Stem Cell Symposium from Sep. 19 to Sep.21, 2018.

Third-party Cell Quality Certification

To ensure safety, Helene partner with Takara Bio Inc. to implement rigorous, high-standard testing protocols. Following these exact specifications, our state-of-the-art in-house lab executes extensive quality control measures before any cells are cleared for patient administration. Through this independent, rigorous third-party validation, the uncompromised quality of our cellular products is fully authenticated, conclusively proving that the therapies we deliver consist of authentic, high-purity mesenchymal stem cells. Furthermore, our proprietary cultivation process guarantees a completely sterile environment with zero risk of contamination, and our cells are clinically verified as non-tumorigenic (retaining no risk of oncogenesis) while maintaining their definitive, pluripotent differentiation capabilities. Upon treatment, each patient is provided with a comprehensive dossier containing these official, certified laboratory reports.

6Facial Injections

Facial cleansing → Applying numbing tape and numbing cream to the face (wait 20–30 minutes) → Facial injections tailored to your personal preferences → Cooling with ice → Applying anti-inflammatory and soothing sun protection cream

Injection

Micro-needle (24G)

※ The advanced U225 device (a premium injector engineered in France specifically for intradermal injections). We are able to precisely and mechanically deliver a consistent amount of the treatment solution to the exact same depth every time.

▼Risks and side effects of treatment Hearing loss, dizziness, tinnitus, kidney damage, hypoglycemia, infection, etc. (anaphylactic reaction (cold sweat, nausea, vomiting, abdominal pain, difficulty breathing, low blood pressure), pain at the puncture site, internal bleeding, nerve damage)

7End of Treatment

Prior to your departure, our medical concierge team will provide you with comprehensive post-treatment care guidelines to ensure an optimal and seamless recovery. To prioritize your safety against residual effects of medication or mild post-procedure discomfort, please refrain from commuting to the clinic via self-driven cars or motorcycles. We strictly advise arranging private, chauffeured transport or utilizing public transit for your return journey.

If you have any concerns after you return home, please contact us at any time. Our staff and doctors will respond promptly.

If you would like to consult with us before visiting our clinic, please contact us using the form below.

Stem cell therapy for specific diseases

Arteriosclerosis

Improving the environment of vascular endothelial cells by injecting mesenchymal stem cells can slow and improve the progression of arteriosclerosis.

Chronic Knee Pain

By suppressing joint inflammation and promoting cartilage repair and regeneration, stem cells help restore the intra-articular structure, which can significantly alleviate pain.

Hair Regeneration

By injecting adipose-derived stem cells directly into the scalp to activate hair follicle stem cells, this treatment restores the normal hair cycle and promotes hair growth.

Skin Rejuvenation

Injecting mesenchymal stem cells stimulates the production of essential dermal components, including collagen, elastin, and hyaluronic acid.